Kynurenine - Depression & Brain Aging Effects (Reduced By Exercise)

CycloneCyclone rich in satisfats
edited October 2014 in General Discussion

kynurenine seems to be created in the body when you are under stress. You can read the wikipedia link for the basics:


•Exercise training activates PGC-1α1:PPARα/δ:KAT in mouse and human skeletal muscle

•PGC-1α1 induces skeletal muscle kynurenine aminotransferase (KAT) expression

•Skeletal muscle PGC-1α1 controls plasma and brain kynurenine/kynurenic acid balance


kynurenine vs depression, affects serotonin levels in the brain (plus other neurotoxic effects)


exercise reduces kynurenine in the body

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