Increasing Caffeine Clearance With Herbs/supps (Cyp1A2 Activity)
I'm interested to know if we can speed up caffeine clearance from the blood by ingesting a 'pill' (or consuming a herb).
On the face of it ('google research'), one way to do this could possibly be to increase the activity of Cytochrome P450 1A2 (CYP1A2).
If we look at the CYP1A2 wiki page here, one candidate listed as an inducer is Echinacea,
but when you actually read the reference study on pubmed, it actually seems to do the opposite;
quote: "Echinacea dosing significantly reduced the oral clearance of caffeine" & "Echinacea (E purpurea root) reduced the oral clearance of substrates of CYP1A2"
Another potential candidate mentioned (google again) was Ginkgo Biloba, but the consensus (new studies i think?), seem to show G.Biloba has no effect on CYP1A2.
So that's as far as i've got at the moment.
Hopefully some of you good peeps will have more to offer. Thanks All.
fake it till you make it