Can you expand on what mTOR means? I tried only having coffee before and the fat gave me a stomach ache, not ideal, probably didn't mix with the intense athletic training, just hitting weights would prob be fine. Tried having nothing before, same prob just stomach growling and weakness during a time when performance is critical. For me, a scoop of protein 1/2hr before was easy on the stomach and staved of hunger, I think that what is being done dictates the variance in protocol.
mTOR inhibitors, e.g. rapamycin, are already used to prevent transplant rejection. Rapamycin is also related to the therapy of glycogen storage disease (GSD). Some articles reported that rapamycin can inhibit mTORC1 so that the phosphorylation of GS(glycogen synthase) can be increased in skeletal muscle. This discovery represents a potential novel therapeutic approach for glycogen storage diseases that involve glycogen accumulation in muscle. Various natural compounds, including epigallocatechin gallate (EGCG), caffeine, curcumin, and resveratrol, have also been reported to inhibit mTOR when applied to isolated cells in culture; however, there is as yet no evidence that these substances inhibit mTOR when taken as dietary supplements.