High B12 Levels

I just received a b12 blood lab result of 1766, and wasn't supplementing with b12 before. Is that too high?


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  • ACH85ACH85 ✭✭

    First check your units. WellnessFX uses a reference range of >300 pg/mL with no upper limit as healthy, >211-300 as moderate risk, and <211 high risk. I believe you want to balance it with folate as well. I wouldn't worry, but I also wouldn't supplement, and I'd look into b12/folate and your MTHFR gene status, which will affect your levels. 




  • First check your units. WellnessFX uses a reference range of >300 pg/mL with no upper limit as healthy, >211-300 as moderate risk, and <211 high risk. I believe you want to balance it with folate as well. I wouldn't worry, but I also wouldn't supplement, and I'd look into b12/folate and your MTHFR gene status, which will affect your levels. 




    Yea, the levels are pg/ml.


     


    The RBC Folate is at 1049 ng/ml.


     


    I also tested positive for MTHFR C677T mutation.


  • i would repeat the test to see if it is accurate. It is a high value for a non supplementing individual


     


    If a true value the following need to be ruled out.


    Levels of serum vitamin B12 may be raised in:


    • chronic granulocytic leukaemia
    • acute myeloblastic leukaemia
    • acute promyelocytic leukaemia > 1600 ng/l
    • myelosclerosis
    • chronic lymphatic leukaemia
    • carcinomatosis
    • liver disease:
      • acute hepatitis
      • cirrhosis
      • chronic liver disease
      • hepatic coma
    • polycythaemia rubra vera
    • non-leukaemic leucocytosis
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