Saturated Fats To Dull Dopimine Effects?

There' s a post up by Prevention that considers long term, high saturated fat intake harmful for the brain. Wondering if Dave has commented in the past on such opinions on saturated fat and a negative impact on the body's reward system. Perhaps the mentioned studies were tested using low grade fats? Any opinions on this? Thanks.



Here's the part of post pertaining to saturated fat:


Saturated Fat

"Another study, albeit one in rats, contributes to the idea that butter is not in fact back. Researchers at the University of Montreal found that rat diets high in saturated fat (when 50% of all calories come from an unhealthy fat, like palm oil or butter) impaired the functioning of their brain’s mesolimbic dopamine system—aka the part that controls motivation and wellbeing, and is often implicated in mood disorders, drug addiction, and overeating. Diets high in monounsaturated fat, like olive oil, didn't show the same association. The study, published in the journal Neuropharmacology, also found that saturated fats dulled the animals’ reward system, spurring them to overeat to compensate for feeling unsatisfied."



Here's the full post:


  • It is really hard to evaluate their conclusions when they do not provide citations or references.  In the academic realm we call this plagiarism and thousands of undergraduates are expelled every year for failing to credit other writers for their work.

  • Likely no control for grass-fed vs grain-fed.  I can buy that a diet so high in O6 will cause brain inflammation issues.

  • RekaReka ✭✭✭

    This is the study: "Dampened mesolimbic dopamine function and signaling by saturated but not monounsaturated dietary lipids" inNeuropsychopharmacology on July 14, 2015. 



    They got the saturated fats from palm, so no grass-fed or grain-fed there, palm doesn't eat either.

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  • No references. They might as well post a picture of a giant turd on the webpage.

  • Thanks Reka, that makes sense on palm.


    They did reference sources, but I agree didn't do so properly.

  • I disagree with the assumption that more dopamine = always good. I was going to guess that it may be from GABA increase from butyric acid, but it appears that palm oil has no butyric acid?

    In any case:

    ^GABA and serotonin may inhibit dopamine, at least in certain cases. The point is, neurotransmitters dance with each other, not alone... And palmitic acid likely affects one or some of these neurotransmitters somehow. It's important in fatty acid synthesis.

    i would argue that nearly all dopamine problems are from TOO MUCH dopamine, and can be corrected by reducing dopaminergic activities. All of this makes common sense, in my opinion. Crack, anybody?

    In conclusion, and "dulls reward system" to "may be harmful to the brain" is a brave leap.

  • Great points HegReg33, especially on dopamine overload. There are a lot of opinions i've seen on over indulgance of porn and its effects on dopamine. Prevention's rational seems to be pretty simplistic in the sense of less dopamine=less happy.


    Side note, do you think "reward" in dopamine production is subjective? In other words, those who have weined off of consuming transfats and sugars no longer attribute those foods with a "reward" and thus don't produce any less dopamine when they don't consume them. Or is reward more innate. Perhaps a butter-loving bulletproof dieter gets their dopamine fix on other things like butter and cacao instrad of those vices.

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