Dear Dave/lostfalco's Biohacking Extravaganza

lostfalcolostfalco
edited December 2013 in General Discussion

Dear Dave, I'm guessing that you read through these forums occasionally so I'm gonna address some of this massive post to you (with various side comments to everyone who might be reading this). This is a huge thank you letter and a catalog of some of my experiences and questions. While I don't agree with everything (I wouldn't have a prefrontal cortex if I did!), I do agree with A LOT and I think it's time I made my thanks public and that I give you the props that you deserve. Here goes.  


Dear BP Community: You guys are awesome! Please feel free to share your thoughts and concerns regarding my ideas with me. The brains of the many outweigh the brains of the few...or the one (especially my tiny, 7 plus or minus 2 mammalian brain). 


Note: some sections are unfinished...I will be making MANY edits in the coming days. Just wanted to start this discussion with you guys. =)


QUICK SUMMARY


Favorite Noot: Armodafinil

Favorite Device: laser (or maybe laser + oxygen + BP Vibration plate...it's so hard to choose)

Favorite Racetam: Phenylpiracetam

Favorite Brain Food: Raw Eggs

Favorite Short Term Memory Booster: Vassopressin (very dangerous)

Favorite Stack: PQQ + CoQ10 + laser

 


ABSURDLY LONG EXTENDED DISCUSSION (-continued on next page)


Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

 

 

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Comments

  • lostfalcolostfalco
    edited October 2013

    ABSURDLY LONG EXTENDED DISCUSSION


    THE BIG GUNS: Modafinil/Armodafinil/Adrafinil, Methylphenidate (Ritalin), Amphetamine Salts (Adderall)

    Winner: Armodafinil is my favorite noot overall. Enhances mood, working memory, and wakefulness for me. I've gone from 8 hours of sleep per night (with daily naps) to 6 hours of sleep per night (with no naps). Gaining 2 hours of wakeful energy per day has been priceless. No tolerance in my case. Taken daily for 10 months, 150mg in morning. Long-term risk is unknown so use at your own discretion. Most people cycle, I've found no need to so far.


    Where to Buy: from your local pharmacy with prescription
    http://www.modup.net/
    https://mymodafinil.net/
    http://www.antiaging-systems.com/27-adrafinil-olmifon


    http://awakebrain.com/nootropics/adrafinil.html


    Dear Dave: Thanks for putting yourself out there on national TV and explaining why you do something that is not socially acceptable to a lot of people. Your example gave me the courage to try something that I'm not sure I would have otherwise tried (I convinced my doctor to give me a prescription).


    Note: If anybody wants to read an AMAZING article about how to properly use other stimulants for studying (Ritalin, esp), click here. http://thelastpsychiatrist.com/2007/08/how_to_take_ritalin_correctly.html


    Note 2: Adrafinil is the legal, but weaker version (it metabolizes into modafinil). Here's a podcast on the legal ramifications of using modafinil without a prescription by a lawyer specializing in online pharmaceutical cases. Bottom line: they're not going to hunt you down for importing modafinil but if they arrest you for some other reason AND catch you with prescriptionless modafinil then you will do extra time. http://smartdrugsmarts.com/lawrence-walters-law-surrounding-online-pharmacies/


    BEST VIRTUALLY UNKNOWN (to non-Bulletproofers) NOOT: Lasers, Photobiomodulation, Transcranial Laser Therapy, low-level laser therapy, led therapy, infrared therapy

    Comments: I can't believe that everybody is not using this like crazy. It is awesome but hardly anyone mentions it. It is dose dependent and wavelength dependent. Please do your research before using.


    Look up the work of Karu http://online.liebertpub.com/doi/abs/10.1089/pho.2013.3510, Hode http://www.prima-books.com/NewLaserTherapyHandbook.php , and Hamblin http://www.ncbi.nlm.nih.gov/pubmed/22807422


    Check out these recent studies for more info. The first one is the best. 


    http://www.ncbi.nlm.nih.gov/pubmed/23806754
    http://www.ncbi.nlm.nih.gov/pubmed/23200785
    http://dspace.mit.edu/handle/1721.1/58558
    http://www.ncbi.nlm.nih.gov/pubmed/19995444
    http://www.prima-books.com/Ten-Lectures.php


    Here's a reddit thread with most of the current studies listed. http://www.reddit.com/r/Nootropics/comments/1dccuq/lowlevel_laser_therapy/?utm_source=twitterfeed&utm_medium=twitter


    I use 808nm wavelength light to my forehead at 200 mW...it's called the Vetrolaser, and yes, it's for horses with tendon problems (and for humans with thinking problems). I've also used the 660nm Tendlite with awesome results but 808 is my favorite. It increases ATP production, cerebral blood flow, and neurogenesis by adding energy at the cytochrome C oxidase photoacceptor. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104287/ Can't believe that more people don't rave about this. Has massively enhanced the lives of head injury and stroke victims. Highly recommended, very safe (wear goggles please!)


    Where to Buy: Vetrolaser http://www.vetrolaser.com/

    Tendlite http://www.amazon.com/Anti-inflammatory-Pain-Joint-Management-Fibromyalgia/dp/B004QECAU4/ref=sr_1_1?ie=UTF8&qid=1373808986&sr=8-1&keywords=tendlite


    Goggles http://www.eaglepair.com/english/productDetails.aspx?GlobalPage_ID=76

    Note: I'm currently researching WAY cheaper lasers that are just as effective. I'm pretty sure I've found a few high quality options in the $25-$50 range. I'll keep you guys posted.  


    Here's a cool customer review of Eagle Pair OD 4+ goggles (he reviews goggles that block different wavelengths than mine, but same brand). Just scroll down the page for the review. http://laserpointerforums.com/f52/eagle-pair-safety-glasses-both-200-450nm-580-760nm-powerfulpurchase-ebay-55221.html

    Conclusion: "Completely blocks the specified wavelengths. You need not worry about any eye damage as a result of the beam hitting the glasses." Note: he used a 270mw laser with a 660nm wavelength and a 940mw with a 445nm wavelength.


    Dear Dave: I got this idea from you. There is no way that I would have ever pointed a laser at my head if I had not heard you talk about it in a podcast and watched you do it in a YouTube video. http://youtu.be/Sc7NNr8KnYs?t=9m36s   Seriously man, thank you! You've permanently changed my life.


     


    THE ULTIMATE LASER PROTOCOL aka TULIP (another nod to Longecity's Abelard Lindsay, inventor of CILTEP http://www.longecity.org/forum/topic/51732-chemically-induced-ltp/ )

    The Core: PQQ (20mg) + CoQ10 (300mg) + laser. Clearly, this stack centers around mitochondrial function and OXPHOS. So far, it has been mind-blowing! In a good way. =) The idea is simple: add mitochondria, optimize/enhance mitochondrial energy, optimize clean up.


    Add Mitochondra

    1. PQQ (20mg) http://www.amazon.com/Life-Extension-Biopqq-Vegetarian-Capsules/dp/B00B35AB4Q/ref=sr_1_2?s=hpc&ie=UTF8&qid=1373141740&sr=1-2&keywords=pqq+lef


    Optimize/Enhance Mitochondrial Energy

    2. CoQ10 (300mg) http://www.amazon.com/Life-Extension-Ubiquinol-Enhanced-Mitochondrial/dp/B003VBK5RS/ref=sr_1_1?ie=UTF8&qid=1373141671&sr=8-1&keywords=coq10+lef

    3. laser (808nm 200mw, 2days on, 1day off per 10-20 EEG site)

    4. concentrated oxygen (70% oxygen, 3L/min; 3 minute 'sips' every 10-15 minutes, oxygenation tested with pulse oximeter http://www.walgreens.com/store/c/walgreens-pulse-fingertip-oximeter-c20---measures-oxygen-level-%26-pulse-rate/ID=prod6089451-product?ext=gooPersonal_Care_PLA_Oximeters_prod6089451_pla&adtype={adtype}&kpid=prod6089451&sst=65bde3b7-52ce-49a8-5aa8-0000734a440c )

    5. glucose (3tsp) (Dave, what is your recommendation here? I've been trying rice glucose as well as a glucose-that-shall-not-be-named. I remember that you once recommended 3 teaspoons of glucose in BP Coffee/day to an LSAT student you were coaching. What did you use?)

    6. D-ribose (5g/day) http://www.amazon.com/Jarrow-Formulas-Ribose-Muscle-Powder/dp/B0013OQHA4/ref=sr_1_1?s=hpc&ie=UTF8&qid=1373141879&sr=1-1&keywords=d-ribose+jarrow


    Optimize Clean Up (this still needs significant work on my part)

    7. Oxeloacetate (100mg) http://www.bulletproofexec.com/bulletproof-upgraded-aging-formula/

    8. Glutathione (1 pump every 3-4 hours) http://www.bulletproofexec.com/bulletproof-upgraded-glutathione/


    Future Experimental Directions:

    9. Creatine (I have some on the way and will add it this week)

    10. EPO I may try a hypoxic tent http://www.hypoxico.com/altitude-sleeping-systems.shtml , intranasal EPO http://www.ncbi.nlm.nih.gov/pubmed/23813967 , injectible EPO (anybody have Lance's phone number?), etc. For those of you that blindly follow the media, EPO is not dangerous when used in doctor-monitored, reasonable amounts. If too much, then blood thickens, then death. If proper amount, then more red blood cells, then more oxygen, then more intelligence. It's illegal without a prescription. Hypoxic tent/room/mask is probably the better choice (just ask Michael Phelps http://www.hypoxico.com/ ), though expensive. I'll provide extensive links below on the utterly AMAZING neuroprotective and neuroenhancing properties of EPO. It enhances neuroplasticity, memory, attention, neurogenesis, and hippocampal function while reducing depression. It even affects cognitive function without affecting red blood cells!

    11. Resveretrol Spray http://www.prototypenutrition.com/ProductDetails.asp?ProductCode=R and Leucine (thanks to Joe Cohen from http://selfhacked.com/ for introducing me to this idea...btw, it's not necessary to use spray here)

    12. Metformin http://www.antiaging-systems.com/136-metformin-metforal

    13. Mitoquinone

    14. Idebenone http://www.newstarnootropics.com/index.php

    15. Ursolic Acid Spray (50 sprays) http://www.prototypenutrition.com/ProductDetails.asp?ProductCode=UR I'm very interested in this substance for it's antiinflammatory properties and it's purported ability to mobilize brown fat to burn white fat. I do have concerns about possilble temporary infertility in males and it's somewhat untested state. (see the Examine.com article below for more info)

    16. NADH

    17. IAS's ATP-Boost (combo of ALCAR, ALA, and ATP)


    18. Methylene Blue http://www.amazon.co...=methylene blue ( read this amazing article for info on methylene blue and its relationship to photobiomodulation http://www.ncbi.nlm....pubmed/23806754 )


    Special Acknowledgments:

    Dr. Ward Dean: There is an excellent 4 paragraph discussion of mitochondrial optimization on page 17 of 'Aging Matters Magazine' (Issue 2, 2013) by 'Smart Drugs' author himself Dr. Ward Dean. Here are his recommendations: 1. Increase Number of Mitochondria: PQQ, 2. Increase Mitochondrial Energy Producing Intermediates: D-Ribose (5g/day), Creatine (5g/day), CoQ10SR (100mg/day), NADH, and IAS's ATP-Boost (combo of ALCAR, ALA, and ATP).

    Dave Asprey: Introduced me to the idea of photobiomodulation/low level laser therapy in a podcast.

    Con Stough and Andrew Scholey: Introduced me to the idea of concentrated oxygen and glucose as nootropics.  


    Studies/Sources

    PQQ
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804159/
    http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/540.21
    http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone
    http://www.lef.org/magazine/mag2010/ss2010_Rejuvenate-Your-Cells-Growing-New-Mitochondria_01.htm
    http://examine.com/supplements/Pyrroloquinoline+quinone/


    Source: http://en.wikipedia....inoline_quinone

    "In humans, in one double-blind, placebo-controlled clinical trial conducted in Japan in 2007, supplementation with 20 mg per day of PQQ resulted in improvements on tests of higher cognitive function in a group of 71 middle-aged and elderly people aged between 40-70, who outperformed the placebo group by more than twofold in their standardized memory tests.[18] Interestingly, co-administration of the unrelated compound coenzyme Q10 (CoQ10) further improved performance on standardized memory tests when subjects also took 300 mg per day of CoQ10. No adverse effects were linked to the supplementation, and the results suggested that PQQ, especially when combined with CoQ10, can be used to improve mental status and quality of life in older patients, and help slow or prevent age-related cognitive decline in middle-age patients.

    However, the study was not peer-reviewed and was published in a non-academic journal. No proper scientific study of PQQ effects on memory or cognition in humans has been conducted, as of 2013." 


    Ursolic Acid
    http://www.ncbi.nlm.nih.gov/pubmed/23707761
    http://www.ncbi.nlm.nih.gov/pubmed/21496491
    http://www.sciencedirect.com/science/article/pii/S0006295207004339
    http://www.sciencedirect.com/science/article/pii/S0889159111002066
    http://www.ncbi.nlm.nih.gov/pubmed/23690863
    http://en.wikipedia.org/wiki/Ursolic_acid
    http://examine.com/supplements/Ursolic+Acid/#summary8-2


    Oxygen
    http://www.amazon.com/Advances-Natural-Medicines-Nutraceuticals-Neurocognition/dp/1439893608/ref=sr_1_1?s=books&ie=UTF8&qid=1373161924&sr=1-1&keywords=con+stough+scholey
    http://www.ncbi.nlm.nih.gov/pubmed/18569150
    http://www.ncbi.nlm.nih.gov/pubmed/17395994
    http://www.ncbi.nlm.nih.gov/pubmed/22285726
    http://www.ncbi.nlm.nih.gov/pubmed/17662686
    http://www.ncbi.nlm.nih.gov/pubmed/19429029
    http://www.ncbi.nlm.nih.gov/pubmed/20080151


    Glucose
    http://www.amazon.com/Advances-Natural-Medicines-Nutraceuticals-Neurocognition/dp/1439893608/ref=sr_1_1?s=books&ie=UTF8&qid=1373161924&sr=1-1&keywords=con+stough+scholey


    EPO
    http://neuroscene.com/?p=234
    http://miskowiak.dk/publications.html
    http://www.amazon.com/Enhancing-Human-Capacities-Julian-Savulescu/dp/1405195819/ref=sr_1_1?ie=UTF8&qid=1372136376&sr=8-1&keywords=enhancing+human+capacities


    Recent Meta-Analysis:

    "METHODS: We systematically reviewed the published findings from animal and human studies exploring the potential of EPO to treat depression-related cognitive dysfunction and depression.

    RESULTS: We identified five animal studies (two in male rats, two in male mice and one in male rats and mice) and seven human proof-of-concept studies (five in healthy volunteers and two in depressed patients) that investigated the above. All of the reviewed animal studies but one and all human studies demonstrated beneficial effects of EPO on hippocampus-dependent memory and antidepressant-like effects. These effects appear to be mediated through direct neurobiological actions of EPO rather than upregulation of red cell mass.

    CONCLUSIONS: The reviewed studies demonstrate beneficial effects of EPO on hippocampus-dependent memory function and on depression-relevant behavior, thus highlighting EPO as a candidate agent for future management of cognitive dysfunction and mood symptoms in depression. Larger-scale clinical trials of EPO as a treatment for mood and neurocognitive symptoms in patients with mood disorder are therefore warranted." 


    Photobiomodulation/Low Level Laser Therapy

    (see above discussion for studies)

     


    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • lostfalcolostfalco
    edited December 2013

    COFFEE--Bulletproof Coffee + grass-fed butter (Kerrygold) + MCT/Octane Oil


    Comments--have been drinking this for over a year now with extremely good results. Mental clarity, focus, appetite regulation, etc.

    Dear Dave--Um, you may have heard of this one. =) What I really love about your coffee (besides the intermittent fasting and mental benefits) is the lateral thinking involved here. Thanks for this. I get my Brain Octane soon and I'm really looking forward to trying it!


    NEUROSTEROIDS: Pregnenolone, DHEA

    Comments-- Neurosteroids are a fascinating new (relatively) brain enhancement area. Pregnenolone has worked amazingly well for me so far. Recent studies have shown safety at over 500mg per day for 3+ years (for schizophrenia patients), but most of the time 50mg or even 5mg will do (Ray Sahelian's recommendation). Please practice minimum effective dosing! Megadosing is almost always ill advised. My principle is this: All is Goldilocks. Not too hot, not too cold...just right. I realize this principle is mentioned ad nauseum in modern popular science writing so please forgive me. =)


    A recent study shows that Pregnenolone increases NMDA response by a novel route. "PregS approximately doubles the cell’s response to NMDA via a mechanism that is pharmacologically and kinetically distinct from rapid positive allosteric modulation by PregS. The number of functional cell surface NMDARs in cortical neurons increases 60 -100% within 10 min of exposure to PregS"


    Kurzweilai.net Article: http://www.kurzweilai.net/a-new-neurochemical-pathway-for-treating-schizophrenia-and-age-related-mental-decline


    Journal Abstract: http://molpharm.aspetjournals.org/content/early/2013/05/28/mol.113.085696 (the Full Text PDF is on the right hand side of this page)


    Since there's so much conflicting info on the internet about dosing, I went to the university library near my apartment and looked up the official dosing used in various studies. Here's what I found. All the numbers are daily amounts usually half taken in the morning and half taken at lunch.


    Escalating dose: 100mg (2wks), 300mg (2wks), 500mg (4wks) (Marx, 2009)

    100mg for 8 weeks or 500mg for 8 weeks (Savitz, 2010); 5 of the patients took 500mg daily for 3 years

    30mg for 8 weeks or 200mg for 8 weeks (Ritsner, 2010)

    There were no major side effects reported and the conclusion was that 500mg/day was well tolerated...(Marx, 2009); (Savitz, 2010); (Freeman, 1950); (McGavack, 1951)


    Anyway, most of the beneficial effects were reported at the highest dose but obviously this is a very limited set of studies. Additionally, these almost all dealt with schizophrenia patients. So, that's what I found. Weekly escalation might be a thought, but long term safety is based on only 5 patients. That's where the info stands right now.


    The next question I looked up was DHEA. It is one of the other major neurosteroids and has been reported to have mood and attention enhancing effects.


    200mg for 6 weeks (Ritner, 2006)

    150mg for 12 weeks (Strous, 2007)

    These last four are per wikipedia, so verification is needed.

    200mg for 24 weeks (Chang, 2002)

    400mg for 8 weeks (Rabkin, 2006)

    50mg for 12 months (Brooke, 2006)

    50mg for 10 months (Villareal, 2006)


    As you can see, these dosages are pretty high. Again, reported side effects were minimal (but not non-existent).


    Just as a counterpoint, look up the work of Ray Sahelian. He recommends at most 5mg per day at 5 days max with 2 days off. http://www.raysaheli...egnenolone.html


    Here are some very interesting articles on pregnenolone that I've compiled.
    http://www.kurzweila...-mental-decline
    http://molpharm.aspe.../mol.113.085696 (the Full Text PDF is on the right hand side of this page)
    http://www.ncbi.nlm....pubmed/21756978
    http://www.life-enha...th-pregnenolone
    http://www.life-enha...nenolone-review


     


    Here's a special journal issue on neurosteroids. 


     


    http://www.sciencedirect.com/science/journal/09600760/131/1-2


    EPIGENETIC ENHANCEMENT--Sodium Butyrate, Trichostatin A, SAHA, Crebinostat

    Comments--Sodium butyrate has been excellent for me so far. Epigenetics is about to change the world so please get on board if you are not already. It involves changing gene 'expression' without changing the underlying DNA and is ridiculously easy to do compared to gene splicing, etc. You can also increase your body's natural sodium butyrate production by eating fiber. The fiber causes your gut bacteria to release sodium butyrate which is an HDAC2 inhibitor that has been shown to massively increase learning and intelligence (mostly in rodents so far though). http://picower.mit.edu/ NaB does have other effects besides impacting brain function so be careful. Here's a recent summary I wrote on the current state of the research. 


     


    NaB is a non-specific HDAC inhibitor. Current research indicates that inhibiting HDAC2 specifically is the primary enhancer of learning and memory.http://www.ncbi.nlm....les/PMC3498958/ Attempts are currently underway to create specific HDAC2 inhibitors http://www.ncbi.nlm....les/PMC3447535/ but it's a difficult task. Check out these two articles on NaB as an HDAC inhibitor http://jn.nutrition....33/7/2485S.long and also for it's role in learning and memory. http://www.ncbi.nlm....pubmed/23615664


    Here's a quick little summary of sodium butyrate's effects. https://www.caymanch...m/catalog/13121

    And, of course, the wiki on butyric acid. http://en.wikipedia....ki/Butyric_acid


    Here's a quote on HDAC inhibition:

    "Inhibitors of HDACs regulate CREB-dependent transcription (e.g. Fass et al., 2003) and enhance cognition (reviewed in Haggarty & Tsai, 2011). In the case of contextual fear conditioning, enhancement of cognition by HDAC inhibitors is dependent on the functioning of CREB (Vecsey et al., 2007). HDACs are a family of 18 isoforms that catalyze the deacetylation of the ε-amino group of lysine side chains in histone N-terminal tails, and also in numerous other intracellular proteins (Grozinger & Schreiber, 2002Choudhary et al., 2009). The catalytic mechanism of 11 of these HDACs is critically dependent on a divalent zinc cation coordinated by conserved histidine and aspartate residues within the catalytic site (Bressi et al., 2010). Zinc-dependent HDAC isoforms have been categorized into classes based on structural analyses of the active sites and other domains in these proteins and inhibitor sensitivity (Bradner et al., 2010): class I (HDACs 1, 2, 3, and 8); class IIa (HDACs 4, 5, 7, and 9); class IIb (HDACs 6 and 10); and class IV (HDAC11)."


    I hope that get's you guys started! Epigenetics is one of the coolest areas of science in our generation. Don't forget to keep following the Picower Institute.http://picower.mit.edu/ They are doing some very cool work in this area.


    Here's an excellent popular work on epigenetics that I read a few months ago. http://www.amazon.co...rds=epigenetics


    Here's the entirely free "Cognitive Enhancers" issue of Neuropharmacology. I recommend reading the whole thing...it's awesome!http://www.sciencedi...nal/00283908/64 


    ELECTRICITY--tDCS + D-cycloserine

    Comments--Studies have shown that taking D-cycloserine 2 hours before doing tDCS causes the typical 1 hour after effects of tDCS to last for over 24 hours! Yup, that's real. This has been tested and verified in humans but, amazingly, I haven't seen any biohackers try it yet. I have a major concern about excitotoxicity on this one but I am ridiculously intrigued. Could I learn an entire semester's worth of info in a weekend? Maybe. Most of the testing has been done in the motor cortex, but I see no reason this wouldn't work in the dlpfc. Anybody tried this? I have my tDCS and a 10 pack of D-CYC in front of me but this is very risky. D-CYC has serious side effect potential and 24 hours of anodal excitability could very possibly fry one's brain. Not gonna try it without A LOT more knowledge. Ideas? Experiences? Would love some feedback on this intriguing idea. I've been doing tDCS for over three years now and have this device.http://www.scriphessco.com/products/activa-activadose-ii-iontophoresis-device/ Here's a very inexpensive option for people to try http://tdcs-kit.com/ and another relatively cheap option. http://www.biocurrentkit.com/ Optimal electrode placement is key here (see 10-20 EEG chart). Anode excites, Cathode inhibits.


    OXYGEN--Oxygen concentrator, scuba gear, etc.


    Comments--100% oxygen breathed for 3 minutes has been shown to increase oxygen blood levels and greatly increase learning...especially memorization and reaction time. Studies have also shown that 30% and 40% at 8L/min work as well. It seems that the dangers of oxygen mostly occur when someone breathes it for a much greater time than this.


    Source: http://www.amazon.com/Advances-Natural-Medicines-Nutraceuticals-Neurocognition/dp/1439893608/ref=sr_1_1?ie=UTF8&qid=1371426860&sr=8-1&keywords=advances+in+natural+medicines+nutraceuticals+and+neurocognition


     


    Thoughts on Air: I've already added an oxygen concentrator and scented oils and now I'm looking into hyberbaric chambers or hyperoxic tents. Altitude training/sleeping (10-14 hrs/day) causes your body to adapt by making more EPO and thus more red blood cells (erythropoesis). Here's a quote from the wiki on EPO "Multiple studies have suggested that EPO improves memory. This effect is independent of its effect on hematocrit.[6][7] Rather, it is associated with an increase in hippocampal response and effects on synaptic connectivity, neuronal plasticity, and memory-related neural networks.[8][9] EPO may also be an effective treatment for depression.[7][10]" Of course, I'm also looking into the drug EPO. If you are diligent about monitoring your red blood cell levels and you don't over do it, EPO is actually pretty safe. People run into trouble when they use too much, get too many red blood cells, thicken their blood, and die. Check out this AWESOME book for more info. http://www.amazon.co...uman capacities The audio book is much cheaper ($27). http://www.audible.c...72136461&sr=1-1


     


    Hypoxic Tents: http://www.hypoxico....-products.shtml

    Elevation Training Mask (unfortunately, I don't think this will stimulate endogenous EPO): http://www.amazon.co...s=altitude mask

    I'm also looking into Nicergoline. "Nicergoline works by activating the brain’s metabolism and increasing arterial flow, lowering vascular resistance and improving the use of glucose and oxygen. The effect of this is improved mental agility, clarity, perception and concentration." http://www.antiaging...128-nicergoline I've got pure glucose http://www.amazon.co...eywords=glucose and I've got a concentrator, throw in some nicergoline, hop on the vibration plate for 10 minutes and then study for 10 hours. So, hypoxic tent (14 hours) + concentrated oxygen (3 minute sips every 10 min) + nicergoline + glucose. We'll see what happens.


    Note: vinpocetine + vibration plate was awesome. I had energy for hours afterward.

    Recent 'Stack': Concentrated Oxygen + Bulletproof Vibration Plate


    Recent Uber Nerd Stack: Laser (with goggles!) + Oxygen + BP Vibration Plate


     


    Dear Dave: Have you ever tried this combo? Do you have any concerns about oxygen toxicity or accelerated aging?


    NEUROPEPTIDES--Vasopressin, Desmopressin, Oxytocin, Big Dynorphin, Russian Peptides, Glandulars, Semax, Selank, Cerebrolysin

    As we all know, Vasopressin is very dangerous and should be used with extreme caution (and very little water). I have been interested in trying an ultimate neuropeptide stack and using Vasopressin + Semax. I have this Semax. http://www.ebay.com/...=item19db90ed3b Anybody try this? Any cautionary thoughts? It seems to me that this could be a potentially photographic recall stack, but I also want to live. Thoughts here would be appreciated. =)


     


    Where to Buy:


    Vasopressin http://www.antiaging-systems.com/241-vaso-pro-vasopressin

    Desmopressin http://www.antiaging-systems.com/52-desmopressin

    Semax http://www.ebay.com/itm/SEMAX-1-Nootropic-Memory-Boost-Study-Aid-Brain-Health-Focus-Sleep-/111057890619?pt=LH_DefaultDomain_0&var=&hash=item19db90ed3b


    RUSSIAN PEPTIDES: Cerluten, Pinealon, PK-O2, Brain Extract, Cytomaxes, Cytogens, and Peptomaxes

    Comments-- Dr. Vladimir Khavinson discovered that specific peptides interact with DNA and cause gene expression. The DNA for each organ has it's own peptides that turn genes on or off. The basic concept is that certain short peptide chains (generally 3-5 amino acids long) go into promoter sites and cause gene expression. Professor Vladimir Khavinson claims to have isolated over 100 of these chains and tested them on thousands of people over the past 35 years with no side effects.


     


    I recently completed a 10 day run of Cerluten and Pinealon. They were absolutely amazing. Felt like they reset my brain back to optimal functioning levels.


    Here's Prof. Vladimir Khavinson's homepage. http://www.khavinson.ru/


    Here's an excellent summary of the concept of peptide bioregulators. http://www.khavinson.ru/peptide-regulation-of-ageing


    Here's a full-text pdf on the effects of peptide bioregulator Pinealon in Wistar rats. http://www.khavinson.ru/assets/files/2011-Khavinson_Ribakova.pdf


    Here's a YouTube video.


    Where to Buy: Cerluten http://www.antiaging-systems.com/250-peptide-bioregulartors

    Pinealon http://peptideworldcenter.com/presta/en/citogenek-/148-pinealon.html

    PK-O2 http://peptideworldcenter.com/presta/en/folyekony-peptidek/20-pk-01.html


    GLANDULARS--Brain Beef Glandular, Sphingolin, Porcine Brain Glandular

    Where to Buy: Brain Beef Glandular http://www.amazon.com/Nutricology-Brain-Glandular-Capsules-Count/dp/B005HZOWIE

    Sphingolin: http://www.amazon.com/Ecological-Formulas-Sphingolin-Health-Beauty/dp/B003TVEZAI/ref=sr_1_sc_1?s=hpc&ie=UTF8&qid=1371423166&sr=1-1-spell&keywords=spingolin


    Dear Dave: You're one of the few biohackers that I've heard of that has mentioned glandulars. What are your thoughts on brain beef glandulars and sphingolin (bovine myelin sheeth)? What are my mad cow disease risks if I take these?


    EXTERNAL TRIGEMINAL NERVE STIMULATION (the first method of deep brain stimulation available without surgery, used for epilepsy patients, mostly while sleeping), Monarch, Christopher Digiorgio

    Where to Buy: EMS 400 wisdomking.com Oceanside, CA 120 Hz, 250ms, <= 30s on, <= 30s off; asymmetrical biphasic square wave pulse adjustable from 0-100mA; 1.25-inch self adhesive, stimulating electrodes (superior silver-permagel electrodes, Tyco Healthcare/Uni-patch, Wabasha, MN); stimluation between setting 2 and 4 (comfortable level, <20mA)

    One of the early studies used the EMS 400 from wisdomking.com. Here's the EMS 500. http://www.wisdomking.com/product/ems-prom-500-muscle-stimulator The Monarch device is currently available in Europe by prescription only.


    TRANSCRANIAL ULTRASOUND STIMULATION--Stuart Hammeroff Study of quantum brain theory fame (along with elite physicist Sir Roger Penrose), 8mhz stimulation, recently 2mhz has been proposed as another very promising option.
    http://www.ncbi.nlm.nih.gov/pubmed/22664271 "We suggest TUS acts via intra-neuronal microtubules, which apparently resonate in TUS megahertz range."


     


    Here's Dr. William Tyler's site. http://www.tylerlab.com/projects/ultrasound He's attempting to create commercial versions of TUS through his company Neurotrek. http://neurotrek.com/


     


    Here's a video of someone undergoing transcranial ultrasound, just so you don't think I'm too crazy.



     


    Another Study: http://www.ncbi.nlm....pubmed/23596496


     


    News


    https://asunews.asu.edu/20100927_inthenews_ultrasound


    http://www.sciencedaily.com/releases/2013/05/130515094825.htm


    http://www.sciencedaily.com/releases/2013/04/130429164707.htm


    http://thefutureofthings.com/news/10602/ultrasound-helmets-control-brain-activity.html


    http://neurotrek.com/


     


    Where to Buy


    http://www.medexsupply.com/product_info.php?products_id=23548


    http://www.tylerlab.com/projects/ultrasound


    TRANSCRANIAL RANDOM NOISE STIMULATION--has been shown to improve math skills. A company called Neuroconn sells tRNS's for $4000.
    http://www.news-medical.net/news/20130518/Transcranial-random-noise-stimulation-allows-the-brain-to-work-more-efficiently-say-researchers.aspx

    Where to Buy: http://www.neuroconn.de/dc-stimulator_plus_en/


    NEUROFEEDBACK--the Peanut (nIR), NeurOptimal

    I was able to purchase this device used (at a significant discount) from a kindly biohacker. http://www.upgradeds...in-trainer.html I've been using it recently with good results and I can't wait to see what sort of improvements I can make.

    NeurOptimal--I'm currently looking into renting one of these to try it out for peak performance purposes.


    RACETAMS--Piracetam, Aniracetam, Phenylpiracetam


    COLD THERMOGENESIS--CoreControl, Cold Thermogenesis Vest

    I have the CoreControl Glove and have just begun experimenting with it for brain, sleep, and athletic enhancement. I'll report back when I have more information.

    Where to Buy: http://corecontrolcooling.com/product/corecontrol/


    MECHANICALLY INDUCED SYNESTHESIA--I've had this idea for years now and I'm ready to try it. My theory is that the Brainport device (pioneered by neurosceience legend Paul Bach-y-Rita) could be used by healthy people as the ultimate learning and memory tool. For those who aren't familiar with it, the Brainport (there are other devices like it) consists of a grid of electrodes that are placed on your tongue. A video camera feeds electrical patterns into the electrodes based on what it films in the environment. Devices like this have been used for decades in the military and they are now being used to give blind people sight. Anyway, it seems to me that the Brainport could be worn while studying and the camera could be pointed at whatever it is that you wanted learn. Instantly, you would have an entirely extra sense to help you remember your assignments. This could be absurdly powerful in my opinion. Is there anyone out there who would be willing to build me one? (They are only for sale in Europe right now for $10,000). There are iterations that also consist of electrodes on the back or stomach and another version that uses sound waves instead. I've messed around with an app that works this way in conjunction with the camera on my phone. Yes, I staggered around my apartment for two hours one Saturday with a blindfold on and my video phone outstretched in front of me. Serious nerd alert. So, any engineer out there who could put together a mouthpiece electrode and write an app to go on my phone? We can talk about price. =)

    Where to Buy:


    Brainport http://www.wicab.com/en_eu/


    http://www.seeingwithsound.com/winvoice.htm


    http://en.wikipedia.org/wiki/Paul_Bach-y-Rita


    CES--Russain sleep machine

    Comments--I've been using this for 20 minutes every night while I meditate before I sleep. I love it. I always seem to need less sleep and I wake up with energy and a positive mood.

    My Device-- http://www.amazon.com/Sota-Professional-Edition-Model-BT7/dp/B000NB88C8/ref=sr_1_1?ie=UTF8&qid=1371412752&sr=8-1&keywords=sota+bio+tuner


    THETA-BURST STIMULATION


    TRANSCRANIAL MAGNETIC STIMULATION


    ESSENTIAL OILS--Rosemary, Peppermint

     


    My Fundamental Approach


    When I sat down to optimize my life, my brain asked this: "what are the absolute, rock-bottom fundamentals?" Answer: qualia (ie. internal subjective mental states). Question 2: "What causes qualia?" Answer: physiology (sorry mystical people, physiology seems like a better guess to me than other non-physical entities). Question 3: "What does the physical world consist of?" Answer: the standard model of particle physics. 


     


    So, I hopped on the standard model wikipedia page, did a little reading, and started asking more questions. How can I optimize my spacetime? How can I optimize my photons? How can I optimize my electrons, etc.? I also asked myself about what I consume the most. I came up with obvious answers like air, photons(not sure 'consume' is the right word here, but you get the idea), water, and food.


     


    I'm sort of surprised that more people don't thoroughly consider the things they consume the most first: air, water, light, sound, smells, and food (these categories are imperfect and not necessarily in order...though close). People seem to focus so much time on food and vitamins in particular (which is actually just a very small subcategory of food). When you think about how much air and water and light you consume it becomes evident why taking one tiny supplement or pill doesn't always work. It's a miniscule fraction of what you are consuming.


     


    Covey's Countdown (aka The Ultimate Time/Motivation Hack)


    One of the late, great Stephen Covey's Seven Habits is 'begin with the end in mind'. With that in mind, I decided to determine my end. Based on family history, statistics, etc. I currently plan on dying on January 1st, 2060 (sorry Ray and Aubrey, I really hope I'm wrong!). I keep a countdown timer running on my computer and on my phone to remind me that life is precious. As I write this, I have 16,971 days, 13 hours, 9 minutes, and 23 seconds left. I always thought that 'live like you're gonna die tomorrow' was a ridiculous principle anyway. ha 


    http://www.timeanddate.com/countdown/create


    https://play.google.com/store/apps/details?id=hdn.android.countdown&hl=en


     


    The Intelligence Feedback Loop (IFL)


    One of My Guiding Principles: use intelligence to create intelligence. I decided to start by figuring out what the number one smart drug was and then use the enhancement caused by that smart drug to study other noots...kind of a virtuous feedback loop, if you will. Anders Sanberg has said that modafinil is the best and I think he's right.


     


    Thoughts on the Oft Mentioned "Limitless" (spoiler alert!)


    The best part of the movie in my opinion is the part at the end where he is taking zero drugs. My ultimate goal is to take as few things as possible. This is the reason that my stack does not consist of 14 different pharmaceuticals. Interactions and measurements become increasingly unpredictable as the number of substances increase. 


     


    Justification for All My Experiments


    Obviously, the first question that probably comes to mind is this: If you believe in taking a minimal number of things then why are you trying EVERYTHING? Answer: I start with what I think is most fundamental and then build on that foundation over time. I pretty much take life on modafinil as my new baseline and everything else is judged on how it interacts with moda. I take one and only one 150mg armodafinil in the morning and then listen to my body very closely the rest of the day. If I'm tired, I rest. When I feel sleepy, I go to bed. You will never see me attempt a 60 hour straight sleepless experiment (unless the face eating zombie apocalypse begins). Additionally, most of my experiments are short term. Most healthy people are going to be fine trying Vasopressin once (not all, however...there is risk). If you take it every day then you are probably going to run into serious problems. I take moda daily because it's extremely well studied, has low addiction potential, and enhances my quality of life significantly. Almost nothing has been studied for 30+ years in a rigorous manner, so I am also taking risks here. Will I get brain cancer at 62? Possibly. I realize that I have to acknowledge this and weigh my decisions accordingly. 


     


    All is Goldilocks (aka Goldilocks is a Harsh Mistress)


    Almost everything follows an inverted U-shaped dose response curve. Always look for the balance, the just-right...not too hot, not too cold. Megadosing is for mega-fools. 


    On the Virtues of Devices

    Reasons that Devices Freaking Own: 1) specificity, 2) much lower potential for tolerance. Specificity: molecules and drugs usually have MANY different roles in the body. If you want to target your dlpfc there is NO better way than running a current across it or enhancing it with light. You don't rev up your entire system or deal with as many complications (though there are still some). Tolerance: our bodies are adaptation machines. Dawkins talks about the evolution of evolvability and epigenetics is showing how insanely fast the information content of our bodies can change in response to environment. I think of humans as this: continually expressing information patterns (word tenses chosen intentionally). What's crazy is that not only are we continuously being recreated (we are more like a river than an unchanging structure), but the underlying information itself is constantly changing (mainly your epigenome since your DNA doesn't change much over the course of your lifetime). Mother nature is a ruthless optimizer. If not used, then discarded. If getting nutrient from diet, then stop making endogenously (just ask any bodybuilder about the size of his raisonettes). Devices can often (not always) be used to get around this. There is virtually no way for my body to significantly adapt to a vibration plate that increases blood flow to my brain (although nature is crafty and my tiny mammalian brain is not that smart so I could be wrong).


     


    On Learning and Memory


    Check out (if you already haven't) this awesome article on how to properly use Ritalin/amphetamines to study. Summary: imitate test taking conditions as accurately as possible while studying. Take Ritalin before you study and take it before the test. Make sure you are in exactly the same state mentally and emotionally while taking the test as you are while studying. http://thelastpsychi..._correctly.html 


    I've found this principle hugely important: 'practice' for a test, NEVER 'study' for a test. It'll change your academic life. (this is not my own idea btw, just found it helpful)


    Additionally, this principle: memory is 're-creation', not 'retrieval'. You practice recreating a memory. It is nothing like searching through an old file cabinet or wandering the rows of a library looking for a stored item. It is also 0% like watching a movie stored in your head. 


    This book is fantastic (except for the chapter on memory enhancing supps/drugs) for anybody wanting to get a quick overview of memory.http://www.amazon.co...rt introduction


    For entertaining videos on change blindness (which partially helps explain why memory is nothing like rewatching a stored video) check out Derren Brown's YouTube videos. 


     


    How I Get Free Journal Articles

    I just wanted to share with you guys a quick tip for getting free full-text journal articles even if you are not a university student. I don't know about you guys, but I'm not cool with paying $37 or whatever for a 12 page treatise on the antioxidant properties of rat whiskers. So, in the name of all that's sacred, let me tell you how I got the most recent 50 page photobiomodulation article http://www.ncbi.nlm....pubmed/23806754 by Gonzalez-Lima for free. It's really simple and many of you probably already do it...but I just figured I'd share for those who don't know how to do it yet (sorry non-americans, I've only done this in the U.S. so I'm not sure how to do it elsewhere).  


    So...since I'm not an official university student I just go to my nearest university library, walk up to the "15 minute only" guest computers (with the online catalog, internet, etc.), find the full-text article pdf that I want (university computers have a lot of full-text access that home computers don't), save it to the desktop (usually titled "Damn It Feels Good to be a Gangsta"), open my email, and then send a new message to myself with the article as an attachment or start a new draft message with the article as an attachment (your choice). Then, I just go home, open my email, and download the article while listening to 


    Finally, I read the (nerdy) article and realize that I am actually, nothing like a gangsta at all. The end.


     


    Why Enhancing Healthy People is Justified


    It's kind of astonishing to me that there is debate as to whether it's ok to enhance the brains of healthy people, but there is. Here is one of the MANY arguments in it's favor. It goes like this: If smarter scientists, then more inventions like this. 


     


    The Bulletproof Fundamentals (imo)


    I agree with the true Bulletproof fundamentals which are four: 1. Human performance and wellness by ANY and ALL means necessary (London Real podcast), 2. Measurablilty/Quantified Self (Talking20, Allergy Tests, Zeo, etc.), 3. Relentless tinkering and adjustment until optimal performance and wellness are measurably reached (um, pretty much Dave's life) and 4. helping others attain optimization using the experience and surplus energy/intelligence gained through one's own pursuit of greatness (I couldn't be more in agreement with this). Everybody seems to think it's about butter and grassfed beef and mycotoxins, but it's not...those are means, not ends. 


    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • Nice!  Your aggressive approach is compelling!


     


    Are you using the EMS ProM-400 transcranially? 


     


    Please tell us about your Sota Bio Tuner.  What frequencies does it use?  What is the shape of the wavelength?  


     


    Thanks for posting this!


  • I have many, many questions for you, some of which I haven't even formulated yet, lol! I believe I've seen you post on the longecity forums, have you not? Some questions that arose very quickly, is:


     


    (1) How Exactly are you using the oxygen?


    (2) Have you heard of using CO2 as a bio-hack? I've been reading some of Dr. Peat's work lately, and he recommends using little techniques to saturate your body with CO2: http://www.youtube.com/watch?v=AZkGxrntmTE and http://raypeat.com/articles/articles/co2.shtml


    (3) Have you noticed discernible effects from PQQ? Dr. Kruse recommended this supplement for people when they first started becoming fat adapted, I'm more intrigued by its effects on mitochondria. I'm trying to do everything to enhance my mitochondria, both for sports, and for anti-aging


    (4) How/why were you using D-Ribose? Again, Dr. Kruse (as well as Ben Greenfield) recommended this. I was very intrigued by using this as an alternative fuel source while in a state of ketosis for high intensity activities, and possibly using that + SuperStarch for a 'refeed' that has little to no effect on ketogenesis, but I love aiding my overall well-being and mental state of performance.


     


    Beware..... I have many more questions! 


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • lostfalcolostfalco
    edited July 2013


    Nice!  Your aggressive approach is compelling!


     


    Are you using the EMS ProM-400 transcranially? 


     


    Please tell us about your Sota Bio Tuner.  What frequencies does it use?  What is the shape of the wavelength?  


     


    Thanks for posting this!




    ==============


    Thanks Jason, I appreciate it man. I've got quite a bit more to add over the next few days. 


     


    I have not tried external trigeminal nerve stimulation. It is a brand new procedure and is pretty much entirely for epilepsy patients. I have significant questions as to whether this would be a good idea for a healthy person to try due to possible side effects and very little indication that it would be helpful. I'm just fascinated by deep brain stimulation and this is the first version that I could actually try. I did try to order the device but they wouldn't send it without a prescription...even though it's pretty much just a muscle stimulator. This could easily be hacked but I haven't pushed hard to figure it out because of the very speculative nature of this idea.  


     


    I'll get back to you on the specs for the Bio Tuner. The only reason I'm using it instead of some the devices mentioned in this forum is because I was able to pretty much get it for free. I've noticed a small, yet significant boost from using it but nothing earth-shattering.   


     


    If you have time Jason I would love to hear your thoughts on the new photobiomodulation article. It is pretty much the perfect summary of the current state of transcranial low level laser therapy research. Here's the pubmed abstract. http://www.ncbi.nlm.nih.gov/pubmed/23806754


     


    Have you tried any nootropics yet? I know you've been thinking about it for a while. 


    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • lostfalcolostfalco
    edited July 2013


    I have many, many questions for you, some of which I haven't even formulated yet, lol! I believe I've seen you post on the longecity forums, have you not? Some questions that arose very quickly, is:


     


    (1) How Exactly are you using the oxygen?


    (2) Have you heard of using CO2 as a bio-hack? I've been reading some of Dr. Peat's work lately, and he recommends using little techniques to saturate your body with CO2: http://www.youtube.com/watch?v=AZkGxrntmTE and http://raypeat.com/articles/articles/co2.shtml


    (3) Have you noticed discernible effects from PQQ? Dr. Kruse recommended this supplement for people when they first started becoming fat adapted, I'm more intrigued by its effects on mitochondria. I'm trying to do everything to enhance my mitochondria, both for sports, and for anti-aging


    (4) How/why were you using D-Ribose? Again, Dr. Kruse (as well as Ben Greenfield) recommended this. I was very intrigued by using this as an alternative fuel source while in a state of ketosis for high intensity activities, and possibly using that + SuperStarch for a 'refeed' that has little to no effect on ketogenesis, but I love aiding my overall well-being and mental state of performance.


     


    Beware..... I have many more questions! 




    =================


    Hey Papa! What's up man? Don't worry, I have a million questions too. 


     


    (1) Typical example of oxygen use: On Saturdays I'll typically study for a minimum of 4 hours straight. I'll turn the concentrator on and let it run for that entire time (they're made to run constantly for long periods of time). Following the published studies, I take 3 minute sips of oxygen every 10-15 minutes or so through the nasal cannula. I've found that 70% oxygen at 3L/min is sufficient to get my blood from 98% to 99% oxygenation and give me the benefits of improved memory and ability to work through difficult tasks.


    (2) I have heard of it and I plan to read up on it more. Have you tried it?


    (3) I have noticed a major synergy between the PQQ, the CoQ10, and the laser. The amount of mental energy and speed of thought tempts me to actually use the word 'enhancement' as opposed to just optimization. I'm looking for ways to make it more affordable. Do you know of any high quality, low cost versions of these supplements? I've been using the lef brand which is pretty pricey. I'm also testing $25-$50 lasers from ebay so that everybody can try this. 


    (4) I've been taking 2.5g of D-ribose at 9am and 2.5g at 3pm. I'm basically following Dr. Dean's suggestion to take 5g per day. I like it...but so far I wouldn't consider it an essential element of my experimental stack. Tell me more about superstarch. I've been reading a blog about it recently but I've never tried it.

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • edited July 2013
    Bam!!

    Very nice.

    LLLT and Peptides intrigued me they have.

    Holy shit I'm awesome.

  • Reigning Former Inner Balance "Mad Monk" Champion... :-P 

  • lostfalco do you reckon a halogen floodlight + ziplock bag of water might have a similar effect to your favorite laser?




  • Bam!!

    Very nice.

    LLLT and Peptides intrigued me they have.




    ===========


    They are both really intriguing. If you have time, check out this article on lllt http://www.ncbi.nlm.nih.gov/pubmed/23806754 and this article on peptides. http://www.antiaging-systems.com/articles/323-the-new-russian-peptide-revolution These are two of the best introductions to these subjects that I have found. Come back and let me know your thoughts. I'm just one very fallible person self-experimenting...the more the better. I would love to know Dave's thoughts on peptides. I already asked him a question about oxygen yesterday in the q&a thread, if you wanted ask him about Russian peptides I wouldn't complain. ;) 

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     




  • ========


    Wow, that's very cool. 

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     



  • lostfalco do you reckon a halogen floodlight + ziplock bag of water might have a similar effect to your favorite laser?




    ===========


    That is a very good question. I'm guessing that you checked out this site. http://heelspurs.com/led.html


     


    If you want to contact the guy who runs that site is name is zawy on Longecity. He posted on my thread over there a few months ago on page 3 or 4ish I think. My main concern is that there is a very well documented dose-response curve with lllt. I'm not necessarily saying that it wouldn't work, but that is way more light than most of the scientific studies use. I pretty much just attempted to follow the parameters that were used in the published literature on humans. If you get more info then let me know because that would be a very cost-effective option if it works. Zawy reported getting very tired when he tried transcranial lllt which isn't that surprising given the amount of light. He's a very smart guy though so I wouldn't dismiss the idea out of hand. 

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • RodRod The Rodfather

    Shits crazy! 


    Everything I learned about "biohacking" has been baby steps to "circadian biology", that's where the real biohacking comes in. You can buy a bunch of cool shit to "hack" but if you don't have context, you're not winning. Paleo is just a brand now and too many have opinions, it's on you to read and reread the material to not only find truth but to connect the dots. Much love to everyone who has helped me on my journey for restoring my health, please keep in touch. Feel free to message me with health questions [email protected] 

  • @Lostfalco: I have not done anything with Co2.... yet. In Dr. Peat's video on carbon dioxide he went as far as stating you can go to a welding shop and fill a bag with it and breath it in. He also recommends brown paper bag breathing. I think I will first experiment with Buteyko and Sodium Bicarbonate, then do bag breathing (eventually do that while taking an ice bath), THEN maybe try that welding shop idea lol.


     


    I don't know much about PQQ and what not, so I unfortunately cannot recommend a good brand for a cheaper alternative... BUT there is this: http://www.amazon.com/Life-Extension-Mitochondrial-Optimizer-Capsules/dp/B004B3K6E2/ref=sr_1_2?s=hpc&ie=UTF8&qid=1373681041&sr=1-2&keywords=pqq+supplements half off for awhile, if I were you I'd grab it! I was thinking about using PQQ for the mitochondrial biogenesis... I've been digging through so many citations given by Dr. Kruse and using ketosis for performance, and I think PQQ could aid in that due to increasing the amount of mitochondria I would have to burn fat for fuel. Combining PQQ with CT and a Body By Science style weight training (while using things like an elevation training mask) should be able to potentially aid in my performance quite a bit.


     


    That being said, I really want to get into everything that deals with brain hacking as well. If you could, what would you recommend as the best bang for my buck? In a way, I think you may say Bulletproof Coffee... lol, so besides that? I really want to optimize my ability to learn quickly/memorize massive quantities of information since I'm getting done with summer school and starting back up 'real' school next month (taking courses through Coursera right now on Genetics and Nutrition for Disease Prevention - I still consider that 'real school' lol), but I also want to learn some things on the side.... I want to start a quality blog to track my experiments, and I'd like to learn how to (and then start) making 'mods' for PC video games and make some little ventures with my little brother who began earning money through some. Essentially, I have a lot to learn simultaneously in the next year or two. I'm also going to a CHEK Institute HLC certificaiton seminar in March 2014. I want my brain in high gear, but I don't really have the funds for a 100% bulletproof diet nor extensive nootropics.


     


    If you don't mind: http://www.longecity.org/forum/topic/63228-lostfalcos-extensive-nootropic-experiments/ I saw this wayy back haha. I just thought it'd be good for other people to see and they can check out everyone else's information on that post since it is like 12 pages long. Thanks for posting this awesome thread!


     


    Oh, almost forgot.... What are your thoughts on any of the following: Incandescent lighting (Dr. Peat speaks about using these), Terrarium (UV) lights (for possible vitamin D 'supplementation'), and red lights (as opposed to amber) as a form of a 'red laser' therapy kind of gig? Thanks again!


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • http://www.raypeatforum.com/forum/viewtopic.php?f=3&t=187&sid=a8f45edc4188ed464868a94ce1984a10 this is what made me curious about various forms of lighting, for anyone interested.


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • John BrissonJohn Brisson The Legend Formerly Known as Ron Swanson ✭✭✭

    I don't know If playing guinea pig with your brain is ever a good idea?


    My book Fix Your Gut, is offered on Amazon for $9.99.

     

    I also offer coaching:  http://fixyourgut.com/health-coaching-information/

     

    Please join or like the Fix your Gut Facebook. Also please add me on twitter @FixYourGutJB.

     

    http://www.fixyourgut.com

     

  • Me, or lostfalco, lol? Personally, I won't touch anything until I go and do my own thorough research and couple that with my intuition. That being said, I think things that may alter your neurotransmitters and what not seem to be more risky than other 'brain hacks'. That's why I'm interested in lostfalco's 'best bang for my buck' recommendation. But I'm assuming saving up for Upgraded Coffee would do a lot (oooo how I want me some more of that coffeeee!!) I've seen people make some arguments against creatine for long-term use, but then I know Tim Ferriss has stated it can potentially extend lifespan and protect against Alzheimer's, and other 'bio-hackers' (that Ben Greenfield referenced) use it for clearing up their thought processes.... all that and it's affordable. Seems like a good deal, but if it is bad in the long-term, I'd rather not risk it. 


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • @lostfalco: What has been your experience with Oxytocin (was it in the form of nasal spray?), and how do you/did you use it? Combine it with anything? Look up Dr. Kruse' ideas on DHEA and also, look up Dr. Peat's ideas on Progesterone/Pregnenolone. I forgot to answer you on SuperStarch.... unfortunately, again, I have no experience with it, but Dr. Attia has a presentation on it and he and Ben Greenfield both enjoy it a lot. I see it primarily as an exercise/sports supplement, but you seem to think outside of the box - maybe there can be alternative uses for it. It seems to work really well in keeping Dr. Attia in ketosis, even if he uses a lot and consumes a decent amount of other carbs (totaling up to 89g carbs in one case). I'm also REALLY interested in D-Ribose. I just have to dig into the literature on it. Ben Greenfield uses a supplement that combines D-Ribose and Pinitol, I'd be interested in experimenting with it, or maybe both in isolation THEN combination. With all of Dr. Kruse' ideas/information/hacks on seasonal eating and eating based upon genetics and geography and so much more, I was thinking these would come in handy for times of sustained ketosis. Looking forward to your replies.


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • ===========

    They are both really intriguing. If you have time, check out this article on lllt http://www.ncbi.nlm.nih.gov/pubmed/23806754 and this article on peptides. http://www.antiaging-systems.com/articles/323-the-new-russian-peptide-revolution These are two of the best introductions to these subjects that I have found. Come back and let me know your thoughts. I'm just one very fallible person self-experimenting...the more the better. I would love to know Dave's thoughts on peptides. I already asked him a question about oxygen yesterday in the q&a thread, if you wanted ask him about Russian peptides I wouldn't complain. ;)





    I have come extremely close to purchasing the vetrolaser and excited to try out one or two of the peptides. What other lasers have you been looking into?

    Holy shit I'm awesome.



  • I have come extremely close to purchasing the vetrolaser and excited to try out one or two of the peptides. What other lasers have you been looking into?




    =========


    If I could only purchase one of the peptides, it would be Pinealon. I'd start there and test your response. I loved it, but everybody's physiology is slightly different. Ya know, ymmv and all that stuff.


     


    I would definitely hold off on buying the Vetro. OpaqueMind and I (on Longecity) have had really good results with it but I think we can actually make one that's better AND cheaper. I've been testing this $50 laser from ebay http://www.ebay.com/itm/808nm-200mW-IR-Infrared-Laser-Focusable-Dot-Module-5VDC-/180612529001?pt=LH_DefaultDomain_0&hash=item2a0d587b69 Everything looks good so far, but I still need to purchase a device to test the output before I can recommend it. If you wanted to be an early adopter and try something out I'd recommend going with this first. What's been really cool so far is that Opaque has actually recovered lost brain function using the laser. He said that he suffered brain damage from foolish, youthful drug experimentation and now feels smarter than he ever was (he's still only 21). It's been really cool to see his posts become more and more coherent over the past few months. I'm a healthy male in the 25-35 year old age bracket and have also noticed significant enhancements in mental energy and endurance. The studies on healthy college students at UT Austin also noted 14-day mood enhancement after only 1 treatment lasting 8 minutes. http://www.ncbi.nlm.nih.gov/pubmed/23200785 The godmother of lllt, Tiina Karu, has recently argued that photobiomodulation should be considered a drug equivalent due to the myriad of things it improves. Seriously, this list is crazy. Check it out. http://www.collegeofsyntonicoptometry.com/articles/Is_It_time_to_Consider_Photobiomodulation_As_a_Drug.pdf  

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • @lostfalco


     


    I was studying transcranial electrostimulation a while back.  I would recommend a DIY from scratch instead of trying to re-purpose another device.  Maybe you can pick up where I left off:


     


    http://forum.bulletproofexec.com/index.php?/topic/1673-possible-way-to-boost-your-iq/


     


    I have no doubt that the low laser light treatment is effective, but it is another device that is out of my price range.  Until I am under a different financial situation, I will live vicariously through you!


     


    I have tried all kind of nootropics, but I have stayed far away from Russian peptides.  I have no doubt that they work, but I will wait until I have a better understanding of their biosynthetic function.


  • Wow, lostfalco, that above post resonates with me. What lead to this whole health/performance thing was a history of substance abuse that more or less screwed with my psyche.


    My whole journey has been about 'repairing my mind', and I think that would serve as an excellent tool. 


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • lostfalcolostfalco
    edited July 2013


    @lostfalco


     


    I was studying transcranial electrostimulation a while back.  I would recommend a DIY from scratch instead of trying to re-purpose another device.  Maybe you can pick up where I left off:


     


    http://forum.bulletproofexec.com/index.php?/topic/1673-possible-way-to-boost-your-iq/


     


    I have no doubt that the low laser light treatment is effective, but it is another device that is out of my price range.  Until I am under a different financial situation, I will live vicariously through you!


     


    I have tried all kind of nootropics, but I have stayed far away from Russian peptides.  I have no doubt that they work, but I will wait until I have a better understanding of their biosynthetic function.




    ================


    Hey Jason, I totally hear you on price. I'm currently working with a number of Longecity members to significantly reduce the price so that everyone can try this. Here's a laser for $50 total http://www.ebay.com/itm/808nm-200mW-IR-Infrared-Laser-Focusable-Dot-Module-/260834208555?pt=LH_DefaultDomain_0&hash=item3cbaee2b2bhttp://www.laserlands.net/module/ir/808ml-120-200-1240-bl.html I'm going to be testing the output in the coming weeks but everything looks good so far.


     


    Here's a tDCS device for $39.95. http://tdcs-kit.com/


     


    Another VERY cheap enhancement option related to lllt is methylene blue. They discuss the relationship between MB and lllt in this article. http://www.ncbi.nlm.nih.gov/pubmed/23806754 MB is only $5 for an entire year!


     


    It'd be scary to think what an enhanced version of your brain might be capable of.


     


    I'm currently focused on enhancing mitochondrial function with PQQ + CoQ10 + laser. I've been using the expensive LEF brands but a number of Longecity guys are going to try this brand and report back. (this site won't let me post the link so just go to ebay and type in 'pqq advanced mitochondrial') http://www.ebay.com/itm/20MG-x-100-CAPSULES-PQQ-10-ADVANCED-MITOCHONDRIAL-NERVE-GROWTH-FACTOR-SUPPORT-/121133680403?pt=LH_DefaultDomain_0&hash=item1c34214713


     


    I'm a little concerned about quality here but if it works that would only be $50 for a one time laser purchase + $23/mo for PQQ/CoQ10. If you used MB instead of the laser that would only be $5 additional dollars per year in addition to the $23/mo charge. Completely reasonable for most people.


     


    I know you've been really interested in this stuff for a while and I'd love for you to be able to try it.


    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     



  • Wow, lostfalco, that above post resonates with me. What lead to this whole health/performance thing was a history of substance abuse that more or less screwed with my psyche.


    My whole journey has been about 'repairing my mind', and I think that would serve as an excellent tool. 




    ==========


    I'm sorry to hear that man. It's really cool that you're being so proactive about regaining your mental function. Tbh, your posts sound pretty damn intelligent to me. ha


     


    Here are some studies if you want take a look at them. Obviously, I'm pretty excited about the prospects for mental enhancement and recovery that photobiomodulation may be able to provide. Here's a little cut and pasting for you from a previous post of mine. =)


     


    Low level laser therapy/photobiomodulation has been used very safely for over 40 years and has been shown to significantly enhance mitochondrial function, promote neurogenesis, and aid in the recovery of TBI patients (even years after the injury).


    TBI pilot study

    http://www.ncbi.nlm.nih.gov/pubmed/21182447/


    Mood Studies

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796659/

    http://www.ncbi.nlm.nih.gov/pubmed/23200785


    Recent (excellent) Summary

    http://www.ncbi.nlm.nih.gov/pubmed/23806754


    More Studies

    http://www.ncbi.nlm.nih.gov/pubmed/23281261

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0053454

    http://www.ncbi.nlm.nih.gov/pubmed/22807422

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199299/

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128319/

     

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • Thanks, I suppose all my reading combined with heavy seafood and grass-fed beef intake is kicking in after all! Lol, but thanks for those studies, I'm currently reading them now. Have you had experience with the tDCS-kit you posted that is like $40? I'm thinking about ordering that this up coming week and using it often. I know anthonylee (a user who has posted on these boards and has a youtube channel with DIY tDCS and what not) has used tDCS for language learning - I'd love that to learn Polish, but also, I was wondering if doing a "brain aerobics" or duel n-back session after tDCS would offer great benefits. Maybe tDCS would allow me to do better than normal, thus using more 'resistance' so to speak in the brain aerobics, which would have stronger effects.


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 



  • Thanks, I suppose all my reading combined with heavy seafood and grass-fed beef intake is kicking in after all! Lol, but thanks for those studies, I'm currently reading them now. Have you had experience with the tDCS-kit you posted that is like $40? I'm thinking about ordering that this up coming week and using it often. I know anthonylee (a user who has posted on these boards and has a youtube channel with DIY tDCS and what not) has used tDCS for language learning - I'd love that to learn Polish, but also, I was wondering if doing a "brain aerobics" or duel n-back session after tDCS would offer great benefits. Maybe tDCS would allow me to do better than normal, thus using more 'resistance' so to speak in the brain aerobics, which would have stronger effects.




    ===========


    Cool man. I look forward to hearing your feedback after you check out those articles.


     


    I've used a different tDCS device for a number of years. See if you can pm alexburke over on Longecity. He mentioned that he purchased the $40 tDCS over a month ago. I'll bet he could give you a report. Let me know what he says. I'd love to be able to recommend it because at $40, it seems like it's worth an experiment for just about everyone. At $400, not so much.


     


    If you do get one just let me know and I can give you plenty of info and instructional videos on how to do it properly as well as electrode placements for all different types of enhancement including mood enhancement, working memory (dual n-back), savant-like abilities, etc. It's maybe a little over hyped, but still very cool. Anthony Lee's videos crack me up. ha

    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • If you have the time and don't mind, I'd greatly appreciate it if you PM me on here or through email for information on how to properly use it and what not, I just told my fiance about it and were going to get one together when I get paid next week and alternate its use for 'speed learning' Polish so when we go there in the next year or two we can properly converse with her family, lol. She also has a history of anxiety, depression, substance abuse, among other things, so I adding this to her increasingly paleo template diet could enhance her well-being. Please and THANK YOU, lol!


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • lostfalcolostfalco
    edited July 2013

    No problem man. Just remember, I can't vouch for the $40 device since I have no experience with it. =)


     


    Best training video is at jove.com. It won't let me post the link here, but just go to that site and search for 'electrode positioning montage'. It's the first video that comes up.


     


    This site has a ton of great info http://www.diytdcs.com/


     


    Check out this Longecity thread for personal experiences (it's pretty cool). A number of schizophrenics and depressed patients have seen noticeable improvement. http://www.longecity.org/forum/topic/50076-tdcs-thread/page__st__330


     


    That should get you started. Just remember that electrode placement is somewhat tricky so it usually requires some tinkering and practice. With a little patience, though, it can be pretty cool.

     


    Check out my new site on Revolutionary Cognitive Enhancement! http://www.lostfalco.com/

     

     

  • I just created an account on longecity and messaged alexburke, inquiring about his/her experience with that particular device and why I want/need it. Thanks for all the information and help so far, it's greatly appreciated! Especially those above links, I'm going to go through them today and really dig into this so I know exactly what I'm doing. Hopefully alexburke gets back to me soon and had a fairly decent experience, because I'd love to get into this as soon as possible. Doing all the research I've been doing can only take me so far, eventually you have to get into the trenches and do what you set out to do.


     


    Thanks again for all the information you've put out in these posts. I love it, haha.


    http://equilibriohm.wordpress.com/

    http://biohacksblog.com/

    Natural ability without education has more often raised a man to glory and virtue than education without natural ability. - Marcus Aurelius 

  • This is the tDCs device Anthony recommends and looks pretty good.

    http://www.isokineticsinc.com/category/iop_iontopheresis/product/cg_1335


    Going to look at this "do it yourself" montage.

    Holy shit I'm awesome.

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