Nac Or Glutathione?

Hi all,


 


Recently I started again with some investigation about how to feel 100%, and I concluded that next to the clays (kaolin, zeolite, bentonite, earth), charcoal and b12 that Glutathione might be a smart option. I suffer from brain fog and I know extreme high doses of b12 help with this. However it isn't normal that I need this much b12 and I found research that b12 and glutathione might be related.


 


However, I did also find that many people take NAC which is MUCH cheaper. This gets turned into Glutathione basically. So my question is, why take glutathione and not NAC? I mean there must be a reason Dave sells glutathione apart from making money since he could make money selling NAC too.


 


Thanks


Comments

  • http://www.ncbi.nlm.nih.gov/pubmed/15606130


     


    This is the reason I want to start taking glutathione or nac now. Also there is a big relation to mold and b12 so there must be something to this.


     


    http://www.ncbi.nlm.nih.gov/pubmed/17982599


     


    http://www.ncbi.nlm.nih.gov/pubmed/15349513


     


    Just some stuff to back it up.


  • John BrissonJohn Brisson The Legend Formerly Known as Ron Swanson ✭✭✭

    Two reasons:


     


    1. NAC can harm beneficial biofilm.


    2. At doses over 1,200 mg daily it maybe possible that it is a proxidant instead of an antioxidant.


    My book Fix Your Gut, is offered on Amazon for $9.99.

     

    I also offer coaching:  http://fixyourgut.com/health-coaching-information/

     

    Please join or like the Fix your Gut Facebook. Also please add me on twitter @FixYourGutJB.

     

    http://www.fixyourgut.com

     

  • Two reasons:
     
    1. NAC can harm beneficial biofilm.
    2. At doses over 1,200 mg daily it maybe possible that it is a proxidant instead of an antioxidant.


    thanks for pointing this biofilm risk out. Do you have some references I can check? Definitely want to keep my microbiome happy!

    I started supplementing with 600mg per weekday (to reduce potentially neuroplasiticity (due to neurofeedback) induced inflammation. It's a theory, probably for another thread :smile: ).
  • Do you have research to back this up? I never saw this online.


  • Allright well, I did buy glutathione from Dave. Also did order bulletproof coffee for the first time in my life so curious how that experiment turns out :)


  • you can supplement with precursers that aide methylation to arrive at increases in glutathione, or just supplement with the end result. There can be benefits to both. If you really want to personally bio-hack your own body, knowing your genes if extremely helpful. (Ie: 23andme testing with Geneticgenie analysis from the raw data). On the other hand, when there is a lot going on with the body, say from mold and heavy metal exposure with other vitamin deficencies, it's very hard to figure out the exact mix you might need. So, I've found sometimes taking glutathione is the best way to go. I can't take it every day or I end up feeling worse though. Here is some information to help understand methylation and glutathione production.

    http://www.heartfixer.com/AMRI-Outcomes-Non-CV-Autism-Methyl%20Cycle.htm


    Here is a quote from the above link to give you an example.


    This is a confusing array of biochemistry, but suffice it to say, a defect at any one point in these interlocking cycles will inevitably affect the function of the remaining pathways. While we cannot change your genetics, if we know your weaknesses, we can create "nutritional workarounds" - we can supplement alternative pathways or withhold from your diet molecules that you cannot handle. For example, MTRR (Methionine Synthase Reductase) regenerates Methyl-B12, needed in the detoxification of Homocysteine to Methionine. If your MTRR pathway is defective, then we can "nutritionally bypass" it by supplementing you with Methyl-B12.


    Sounds like bio hacking to me! So someone with the MTRR and MTHFR defects night be able to supplement with methyl folate and methyl B12 instead of taking glutathione.



    John, I was not aware that Biofilm is good in any way. I would also be interested in more info on this.
  • John BrissonJohn Brisson The Legend Formerly Known as Ron Swanson ✭✭✭


    thanks for pointing this biofilm risk out. Do you have some references I can check? Definitely want to keep my microbiome happy!


    I started supplementing with 600mg per weekday (to reduce potentially neuroplasiticity (due to neurofeedback) induced inflammation. It's a theory, probably for another thread :smile: ).




     


    For NAC check the references in my book Fix Your Gut under biofilm. It does not distinguish between the two, beneficial or opportunistic.


     


    http://jac.oxfordjournals.org/content/39/5/643.full.pdf


    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169071/


    http://fixyourgut.com/supplements-combat-biofilm-part-2/


     


    Pro oxidant


     


    http://www.ncbi.nlm.nih.gov/pubmed/22134636


    http://link.springer.com/article/10.1007%2FBF02284964#page-1

    My book Fix Your Gut, is offered on Amazon for $9.99.

     

    I also offer coaching:  http://fixyourgut.com/health-coaching-information/

     

    Please join or like the Fix your Gut Facebook. Also please add me on twitter @FixYourGutJB.

     

    http://www.fixyourgut.com

     

  • John BrissonJohn Brisson The Legend Formerly Known as Ron Swanson ✭✭✭


    you can supplement with precursers that aide methylation to arrive at increases in glutathione, or just supplement with the end result. There can be benefits to both. If you really want to personally bio-hack your own body, knowing your genes if extremely helpful. (Ie: 23andme testing with Geneticgenie analysis from the raw data). On the other hand, when there is a lot going on with the body, say from mold and heavy metal exposure with other vitamin deficencies, it's very hard to figure out the exact mix you might need. So, I've found sometimes taking glutathione is the best way to go. I can't take it every day or I end up feeling worse though. Here is some information to help understand methylation and glutathione production.
    http://www.heartfixer.com/AMRI-Outcomes-Non-CV-Autism-Methyl%20Cycle.htm


    Here is a quote from the above link to give you an example.


    This is a confusing array of biochemistry, but suffice it to say, a defect at any one point in these interlocking cycles will inevitably affect the function of the remaining pathways. While we cannot change your genetics, if we know your weaknesses, we can create "nutritional workarounds" - we can supplement alternative pathways or withhold from your diet molecules that you cannot handle. For example, MTRR (Methionine Synthase Reductase) regenerates Methyl-B12, needed in the detoxification of Homocysteine to Methionine. If your MTRR pathway is defective, then we can "nutritionally bypass" it by supplementing you with Methyl-B12.


    Sounds like bio hacking to me! So someone with the MTRR and MTHFR defects night be able to supplement with methyl folate and methyl B12 instead of taking glutathione.



    John, I was not aware that Biofilm is good in any way. I would also be interested in more info on this.




     


    Bifidobacterium produce biofilm and they are beneficial bacteria http://www.ncbi.nlm.nih.gov/pubmed/24505453. http://www.hindawi.com/journals/bmri/2014/960826/ Not all bacteria that produce biofilm are strongly opportunistic.

    My book Fix Your Gut, is offered on Amazon for $9.99.

     

    I also offer coaching:  http://fixyourgut.com/health-coaching-information/

     

    Please join or like the Fix your Gut Facebook. Also please add me on twitter @FixYourGutJB.

     

    http://www.fixyourgut.com

     

  • I also did order NAC and this one too:


     


    http://www.amazon.com/Foods-Liver-Detoxifier-Regenerator-Capsules/dp/B0013OQLGE/ref=sr_1_1?ie=UTF8&qid=1435849959&sr=8-1&keywords=liver+detoxifier


     


    Did read stuff that b12+nac can be a great combo so just had to try it too. Once everything arrives (10 days!) I will try first NAC+b12+liver detoxifier. After that I will reduce b12, quit NAC+liver detoxifier and try the glutathione. The cheapest long term solution would clearly be if I need less b12 because of NAC and that I can those 2 together. Like John here recommends I will take it slow with the NAC and not take too much :)


  • If you want results for little cost, there are some other places I'd recommend starting first.


     


    1) Eat a diet with at least twice the RDA of all vitamins and minerals (the RDA is just a scam. Should aim to get far more than it)


    2) Detoxadine, High-Dose Vitamin C, High-Dose B Vitamins


    3) Creatine MagnaPower (seeking health optimal creatine), D-Ribose (Dr's best brand)


     


    There's more that could be said here. But thats enough to take you to the next step.


     


    Don't leave out non-ingested stuff like cold immersion.


    Biggest takeaway after several years as a hardcore biohacker: think long-term. Focus on health first before adding in boosters. It works a lot better.
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